Links To And Excerpts From “Obesogens: a unifying theory for the global rise in obesity”

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• Competing paradigms of obesity pathogenesis: energy balance versus carbohydrate-insulin models [PubMed Abstract] [Full-Text HTML] [Full-Text PDF]. Eur J Clin Nutr. 2022 Sep;76(9):1209-1221. doi: 10.1038/s41430-022-01179-2. Epub 2022 Jul 28
• Obesity: a 100 year perspective [PubMed Abstract] [Full-Text HTML] [Full-Text PDF]. Int J Obes (Lond). 2024 May 7. doi: 10.1038/s41366-024-01530-6. Online ahead of print.

Today, I link to and excerpt from Obesogens: a unifying theory for the global rise in obesity [PubMed Abstract] [Full-Text HTML] [Full-Text PDF]. Int J Obes (Lond). 2024 Apr;48(4):449-460. doi: 10.1038/s41366-024-01460-3. Epub 2024 Jan 11.

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All that follows is from Obesogens: a unifying theory for the global rise in obesity [PubMed Abstract] [Full-Text HTML] [Full-Text PDF]. Int J Obes (Lond). 2024 Apr;48(4):449-460. doi: 10.1038/s41366-024-01460-3. Epub 2024 Jan 11.

Abstract

Despite varied treatment, mitigation, and prevention efforts, the global prevalence and severity of obesity continue to worsen. Here we propose a combined model of obesity, a unifying paradigm that links four general models: the energy balance model (EBM), based on calories as the driver of weight gain; the carbohydrate-insulin model (CIM), based on insulin as a driver of energy storage; the oxidation-reduction model (REDOX), based on reactive oxygen species (ROS) as a driver of altered metabolic signaling; and the obesogens model (OBS), which proposes that environmental chemicals interfere with hormonal signaling leading to adiposity. We propose a combined OBS/REDOX model in which environmental chemicals (in air, food, food packaging, and household products) generate false autocrine and endocrine metabolic signals, including ROS, that subvert standard regulatory energy mechanisms, increase basal and stimulated insulin secretion, disrupt energy efficiency, and influence appetite and energy expenditure leading to weight gain. This combined model incorporates the data supporting the EBM and CIM models, thus creating one integrated model that covers significant aspects of all the mechanisms potentially contributing to the obesity pandemic. Importantly, the OBS/REDOX model provides a rationale and approach for future preventative efforts based on environmental chemical exposure reduction.

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