Linking To And Embedding Metabolic Mind’s “Could Stress Be The Hidden Driver of Mental Illness?”

Posted on February 22, 2026 by Tom Wade MD

Here are the links to the article referenced in today’s Metabolic Mind video:

The allostatic triage model of psychopathology (ATP Model): How reallocation of brain energetic resources under stress elicits psychiatric symptoms [PubMed Abstract] [Full-Text HTML] [Full-Text PDF]. Neurosci Biobehav Rev. 2025 Dec:179:106419. doi: 10.1016/j.neubiorev.2025.106419. Epub 2025 Oct 13.

There are 101 similar articles in PubMed.

 

Today, I link to and embed Metabolic Mind‘s “Could Stress Be The Hidden Driver of Mental Illness?”

All that follows is from the above resource.

Could Stress Be The Hidden Driver of Mental Illness? 

Dec 8, 2025 Metabolic Mind Podcast
New research links chronic stress, brain energy, and psychiatric conditions, including PTSD, depression, and bipolar disorder.
Stress doesn’t just impact your mood; it affects how your brain allocates energy. In this interview, Dr. Bret Scher sits down with Dr. Parker Kelly, a postdoctoral fellow at UCSF and the San Francisco VA, to unpack the Allostatic Triage Model of Psychopathology, a new framework proposing that psychiatric symptoms may emerge when the brain is forced to triage limited metabolic resources under chronic stress.
Co-authored with mitochondrial researcher Dr. Martin Picard, this model could shift how we understand and treat mental illness.
In this conversation, you’ll learn:

  • How stress drives brain energy dysfunction
  • Why mitochondria and metabolism may be central to mental illness
  • Which brain networks are impacted by energy deficits
  • The role of predictability and routine in stress resilience
  • How metabolic therapies like nutrition, sleep, and even psychedelics, may support brain energy regulation

This conversation bridges neuroscience, metabolism, and mental health, offering a unique and unifying lens on complex psychiatric conditions.

👉Subscribe to Metabolic Mind for more conversations about metabolic health, metabolic psychiatry, and mental health:    / @metabolicmind  . #MetabolicMind #KetogenicTherapy #Neuroscience
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Resources Mentioned: The allostatic triage model of psychopathology (ATP Model): How reallocation of brain energetic resources under stress elicits psychiatric symptoms

Free CME Clinician Trainings: Are you a clinician who would like to learn more about the science behind these therapies and how to implement them in practice? Earn CME with our growing library of courses from some of the top experts in the field including Dr. Chris Palmer, Dr. Georgia Ede, Dr. Matthew Bernstein and Dr. Bret Scher with more coming soon. Our courses have been made FREE by grants from Baszucki Group, so we can spread these powerful therapies as widely as possible. Earn CME/CNE credits: https://www.metabolicmind.org/for-cli… Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry. Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/ About us: Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them. Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications. Timestamps: 0:00 – Introduction to Dr. Parker Kelley and his work on the effects of stress on brain energy. 5:30 – How good is the evidence linking stress to cardiometabolic dysfunction, immune dysfunction, and psychiatric dysfunction? 7:35 – What is the allostatic triage model? How can this reallocation lead to psychiatric symptoms? 14:58 – What level of stress can produce these adverse reactions? 17:20 – What can someone do to reduce their stress response? 23:37 – What research has been done on psychedelic therapies for stress response? 27:58 – How does the allostatic triage model add to the research on psychopathology without contradicting it? 30:36 – Where to learn more from Dr. Kelley?

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