Today, I review, link to, and excerpt from How Can Insulin Resistance Cause Alzheimer’s Disease? [PubMed Abstract] [Full-Text HTML] [Full-Text PDF]. Int J Mol Sci. 2023 Feb 9;24(4):3506. doi: 10.3390/ijms24043506
The above article has been cited by 31 articles in PubMed.
There are 99 similar articles in PubMed.
All that follows is from the above article.
Abstract
Alzheimer’s disease (AD) is a neurodegenerative disorder associated with cognitive decline. Despite worldwide efforts to find a cure, no proper treatment has been developed yet, and the only effective countermeasure is to prevent the disease progression by early diagnosis. The reason why new drug candidates fail to show therapeutic effects in clinical studies may be due to misunderstanding the cause of AD. Regarding the cause of AD, the most widely known is the amyloid cascade hypothesis, in which the deposition of amyloid beta and hyperphosphorylated tau is the cause. However, many new hypotheses were suggested. Among them, based on preclinical and clinical evidence supporting a connection between AD and diabetes, insulin resistance has been pointed out as an important factor in the development of AD. Therefore, by reviewing the pathophysiological background of brain metabolic insufficiency and insulin insufficiency leading to AD pathology, we will discuss how can insulin resistance cause AD.
Keywords: amyloid beta; dementia; hypometabolism.
