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The impact of a ketogenic diet on weight loss, metabolism, body composition and quality of life [PubMed Abstract] [Full-Text HTML] [Full-Text PDF]. iScience. 2024 Oct 30;27(12):111291. doi: 10.1016/j.isci.2024.111291. eCollection 2024 Dec 20.
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- Summary
- Graphical abstract
- Highlights
- Introduction
- Results
- Discussion
- Resource availability
- Acknowledgments
- Author contributions
- Declaration of interests
- STAR★Methods
- Footnotes
- Supplemental information
- References
- Associated Data
Abstract
A ketogenic diet (KD) is increasingly debated as a countermeasure against nutrition-related modern diseases. While being immunologically beneficial, KD is still suspected of having severe metabolic side effects and negatively impacting general well-being, which prevents its widespread clinical use. We conducted a prospective pre-post interventional study investigating the effects of an eucaloric KD on metabolism, weight loss, body composition, diet adherence, and quality of life. The study had two stages: first, feasibility was tested in healthy, normal-weight participants over three weeks. After positive results, the KD period was expanded to three months, enrolling adults with overweight. Significant weight loss was observed in both groups, reducing body fat without affecting muscle or bone mass and without adverse metabolic changes. Quality of life improved, and fatigue symptoms in subjects with overweight decreased. These findings may help to overcome reservations about KD, encouraging its use as a medical tool for treating nutrition-related disorders.
Keywords: Diet; Human metabolism.
© 2024 The Authors.
Graphical abstract
Highlights
- Weight loss on ketogenic diet is due to visceral fat loss, preserving muscle mass
- Cholesterol levels remain stable during ketogenic diet
- Ketogenic diet enhances general and health-related quality of life
- Fatigue symptoms decrease in overweight individuals on a ketogenic diet
Human metabolism; Diet
