The early recognition of sepsis and septic shock and vigorous treatment of these entities is critical to minimize mortality. The PROcESS Trial (1) addresses some of the questions about current treatment guidelines.
Dr. Scott Weingart’s site, EM Crit Blog–A Discussion of the Practice of ED Critical Care has an outstanding, brief [only 26 minutes] interview with one of the principal investigators of the PROcESS trial at Podcast 120 – The ProCESS Trial with Derek Angus [Show notes], [Listen to the podcast here].
Resources [all these resources are from Dr. Weingart’s podcast show notes].
(1) A Randomized Trial of Protocol-Based Care for Early Septic Shock [Preview–No longer open access]. The ProCESS Investigators, N Engl J Med 2014; 370:1683-1693 May 1, 2014 DOI: 10.1056/NEJMoa1401602
(2) High versus Low Blood-Pressure Target in Patients with Septic Shock [Preview–No longer open access]
(3) No Benefit From Early Goal Directed Therapy. March 19, 2014, Resus.Me–Resuscitation Medicine Education
(4) ProCESS Study: Identify sepsis early and treat aggressively. March 18, 2014. ALiEM–Academic Life in Emergency Medicine.
(5) Early goal directed therapy does not improve outcomes in septic shock (ProCESS). March 21, 2014. PulmCCM–All the Best In pulmonary and critical care.
(6)NEJM Editorial: The ProCESS Trial — A New Era of Sepsis Management. C.M. Lilly, March 18, 2014DOI: 10.1056/NEJMe1402564
(7) Fluid Resuscitation in Severe Sepsis, 2012. Vimeo Video, Chad Meyers, MD.
(8) Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock: 2012 [Full Text PDF]
(9) Surviving Sepsis Campaign: About the Surviving Sepsis Campaign Guidelines Protocols and Checklists Bundles Implementation Kit Education
(10) Surviving Sepsis Campaign Responds to ProCESS Trial Updated 19 May 2014.