“Insulin Analogs” For Therapy In Type 1 Diabetes from Diabetes Education Online

The following is an excerpt from Types of Insulin of Diabetes Education Online:

Human Insulin and Insulin Analogs are available for insulin replacement therapy. Insulins also are classified by the timing of their action in your body – specifically, how quickly they start to act, when they have a maximal effect and how long they act.

Insulin analogs have been developed because human insulins have limitations when injected under the skin. In high concentrations, such as in a vial or cartridge, human (and also animal insulin) clumps together. This clumping causes slow and unpredictable absorption from the subcutaneous tissue and a dose-dependent duration of action (i.e. the larger dose, the longer the effect or duration). In contrast, insulin analogs have a more predictable duration of action. The rapid acting insulin analogs work more quickly, and the long acting insulin analogs last longer and have a more even, “peakless” effect.

Human insulins include Regular Human Insulin and NPH Human Insulin. The newer more modern analog insulins are reviewed below.

The rapid acting insuling analogs are:

  • aspart
  • glulisine
  • lyspro.

The long acting injected insulin analogs are:

  • Insulin detemir (Levemir®)
    • Detemir is usually injected twice a day.
  • Insulin glargine (Lantus®)
    • Glargine is usually injected once daily, but may be given twice daily if needed.

The following are excerpts from Insulin Analogs of Diabetes Education Online:

An analog refers to something that is “analogous” or similar to something else. Therefore, “insulin” analogs are analogs that have been designed to mimic the body’s natural pattern of insulin release. These synthetic-made insulins are called analogs of human insulin. However, they have minor structural or amino acid changes that give them special desirable characteristics when injected under the skin. Once absorbed, they act on cells like human insulin, but are absorbed from fatty tissue more predictably.


Rapid-acting injected insulin analog

The fastest working insulins are referred to as rapid-acting insulin.

They include:

  • Aspart
  • Glulisine
  • Lyspro

These insulin analogs enter the bloodstream within minutes, so it is important to inject them within 5 to 10 minutes of eating. They have a peak action period of 60-120 minutes, and fade completely after about four hours. Higher doses may last slightly longer, but will last no more than five or six hours. Rapid acting insulin analogs are ideal for bolus insulin replacement. They are given at mealtimes and for high blood sugar correction.

Rapid-acting insulins are used in insulin pumps, also known as continuous subcutaneous insulin infusion (CSII) devices. When delivered through a CSII pump, the rapid-acting insulins provide the basal insulin replacement, as well as the mealtime and high blood sugar correction insulin replacement.

Long-acting injected insulin analogs

The insulins that work for the longest period of time are referred to as long-acting insulin. They provide relatively constant insulin levels that plateau for many hours after injection. Sometimes these insulins are called “peakless” insulins.

They have an onset of action within 60-90 minutes, maximum effect in around 5 hours that gradually wanes over the next 12-24 hours.

They include:

  • Insulin detemir (Levemir®)
    • Detemir is usually injected twice a day.
  • Insulin glargine (Lantus®)
    • Glargine is usually injected once daily, but may be given twice daily if needed.

The long acting insulin analogs are suitable for background or basal insulin replacement. It is important to take insulin detemir and glargine at the same time(s) every day to maintain the most predictable levels of basal insulin.


These long-acting insulins can’t be mixed in the same syringe with other insulins – this could change how the insulin works.

Insulin glargine forms clusters when it is injected under the skin. As the individual insulin units detach from the cluster, the insulin analog can be absorbed into the blood stream. The slow break-up of the insulin cluster gives insulin glargine its long action.

After insulin detemir is absorbed into the blood stream, it becomes attached to a blood protein, albumin. It slowly detaches from the albumin over the next 12-24 hours. The low levels of detached or “free” detemir create the insulin effect

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