Links to The 2021 STI Treatment Guidelines Update From The CDC:

CDC’s Sexually Transmitted Infections (STI) Treatment Guidelines, 2021 provides current evidence-based prevention, diagnostic and treatment recommendations that replace the 2015 guidance. The recommendations are intended to be a source for clinical guidance. Healthcare providers should always assess patients based on their clinical circumstances and local burden.

PDF Print Version: Full STI Treatment Guidelines, 2021

Sexually Transmitted Infections Treatment Guideines, 2021

Table of Contents

• Summary and Introduction
• Methods
• Clinical Prevention Guidance
  • STI and HIV Infection Risk Assessment
  • Primary Prevention Methods
  • Partner Services
  • Expedited Partner Therapy (EPT)
  • Reporting and Confidentiality
  • Retesting After Treatment to Detect Repeat Infections
• STI Detection Among Special Populations
  • Pregnant Women
  • Adolescents
  • Children
  • Men Who Have Sex with Men (MSM)
  • Women Who Have Sex with Women (WSW) and Women Who Have Sex with Women and Men (WSWM)
  • Transgender and Gender Diverse Persons
  • Persons in Correctional Facilities
• HIV Infection: Detection, Counseling and Referral
• Diseases Characterized by Genital, Anal, or Perianal Ulcers
  • Chancroid
  • Genital Herpes Infections
  • Granuloma Inguinale (Donovanosis)
  • Lymphogranuloma Venereum (LGV)
• Syphilis
  • Primary and Secondary Syphilis
  • Latent Syphilis
  • Tertiary Syphilis
  • Neurosyphilis, Ocular Syphilis, and Otosyphilis
  • Syphilis Among Persons with HIV Infection
  • Syphilis During Pregnancy
  • Congenital Syphilis
• Managing Persons Who Have a History of Penicillin Allergy
• Diseases Characterized by Urethritis and Cervicitis
• Chlamydial Infections
• Gonococcal Infections
  • Gonococcal Infections Among Adolescents and Adults
  • Gonococcal Infections Among Neonates
  • Gonococcal Infections Among Infants and Children
• Mycoplasma genitalium
• Diseases Characterized by Vulvovaginal Itching, Burning, Irritation, Odor or Discharge
  • Bacterial Vaginosis
  • Trichomoniasis
  • Vulvovaginal Candidiasis
• Pelvic Inflammatory Disease (PID)
• Epididymitis
• Human Papillomavirus (HPV) Infection
  • Anogenital Warts
  • HPV-Associated Cancers and Precancers
• Viral Hepatitis
  • Hepatitis A
  • Hepatitis B
  • Hepatitis C
• Proctitis, Proctocolitis, and Enteritis
• Ectoparasitic Infections
• Sexual Assault and Abuse and STIs
  • Adolescents and Adults
  • Sexual Assault or Abuse of Children
• References
• Terms and Abbreviations Used in This Report
• Workgroup Members

Page last reviewed: July 22, 2021

Content source: Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention