A recent study in the New England Journal of Medicine showed that Liraglutide, a glucagon-like peptide-1 (GLP-1) mimetic, is effective in weight loss. It costs about $1000 a month! See resources below.
Resources:
A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management. [PubMed Abstract] [Full Text HTML] [Full Text PDF] N Engl J Med. 2015 Jul 2;373(1):11-22. doi: 10.1056/NEJMoa1411892.
Another Agent for Obesity — Will This Time Be Different? [PubMed Citation] [Full Text HTML] [Full Text PDF] N Engl J Med. 2015 Jul 2;373(1):82-3. doi: 10.1056/NEJMe1506236.