The Cardiac Causes Of Nontraumatic Sudden Death

Today, I review, link to, and excerpt from StatPearlsSudden Cardiac Death. Allison G. Yow; Venkat Rajasurya; Sandeep Sharma. Last Update: August 8, 2022.

All that follows is from the above resource.


Coronary artery disease is the most common cause of sudden cardiac death, accounting for up to 80% of all cases. Cardiomyopathies and genetic channelopathies account for the remaining causes. The most common causes of non-ischemic sudden cardiac death are cardiomyopathy related to obesity, alcoholism, and fibrosis.

In patients younger than 35, the most common cause of sudden cardiac death is a fatal arrhythmia, usually in the context of a structurally normal heart. In patients from birth to 13 years, the primary cause is a congenital abnormality. In patients aged 14 to 24 years, the cause of sudden cardiac death is attributed to hypertrophic cardiomyopathy (HCM), arrhythmogenic right ventricular cardiomyopathy (ARVC), congenital coronary anomalies, genetic channelopathies, myocarditis, Wolff-Parkinson-White syndrome, and Marfan syndrome.

Common Causes of Sudden Cardiac Arrest

Ischemic Heart disease

  • Myocardial infarction
  • Anomalous coronary origin
  • coronary spasm

Inherited Channelopathies 

  • Long QT syndrome (LQTS)
  • Short QT syndrome (SQTS)
  • Brugada syndrome
  • Early repolarization syndrome
  • Catecholaminergic polymorphic ventricular tachycardia (CPVT)


  • Alcoholic
  • Hypertrophic
  • Idiopathic
  • Obesity-related
  • Fibrotic
  • Arrhythmogenic right ventricular cardiomyopathy (ARVC)
  • Myocarditis

Heart Failure

  • Nonpreserved  ejection fraction (EF) systolic heart failure (EF less than 35%)

Valve disease

  • Aortic stenosis

Congenital diseases

  • Tetraology of Fallot


Each year, approximately 0.1% of the United States population experiences a medical services-assessed, out-of-hospital cardiac arrest. European studies have a similar incidence ranging from 0.04% to 0.1% of the population. The median age in the US is between age 66 and 68. Males are more likely to suffer from sudden cardiac arrest.

While rare, sudden cardiac death is the leading cause of nontraumatic cause of death among young athletes. In the general population, sports-related, sudden death from any cause is 0.5 to 2.1 per 100,000 yearly. Sports-related, sudden deaths are higher in elite athletes with an incidence of 1:8,253 per year per the National Collegiate Athletic Association (NCAA). NCAA Division I male basketball players have a 1:5200 incidence of sudden death.

A circadian peak of sudden cardiac death occurs between 6 am and noon, and a smaller peak occurs in the late afternoon. The overall incidence of sudden cardiac death is higher on Mondays. 

History and Physical

Some patients experience palpitations, dizziness, or near syncope prior to sudden cardiac arrest. Almost half of the patients who have sudden cardiac arrests report no symptoms prior to collapse.

The American Heart Association recommends cardiovascular screening for high school and collegiate athletes. This includes an evaluation of the athlete’s personal and family history and a physical exam.  Screening should follow the AHA guidelines:

Personal History

  1. Chest pain/discomfort/tightness/pressure related to exertion
  2. Unexplained syncope or near syncope
  3. Excessive exertional and unexplained dyspnea/fatigue or palpitations, associated with exercise
  4. Prior recognition of a heart murmur
  5. Elevated systemic blood pressure
  6. Prior restriction from participation in sports
  7. Prior testing for the heart, ordered by a physician

Family History

  1. Premature death (sudden and unexpected) before age 50 attributed to heart disease in > 1 relative
  2. Disability from heart disease in close relative less than age 50
  3. Hypertrophic or dilated cardiomyopathy, long-QT syndrome, or other ion channelopathies, Marfan syndrome, or clinically significant arrhythmia specific knowledge of certain cardiac conditions in family members

Physical Examination

  1. Heart murmur should be evaluated with the patient both supine and standing or with Valsalva
  2. Femoral pulses to exclude aortic coarctation
  3. Physical stigmata of Marfan syndrome
  4. Brachial artery blood pressure (sitting position), prefer both arms

Routine ECG testing is not recommended for student-athletes. Students found to have an abnormal exam or those with a positive personal or family history may be referred for cardiac testing including ECG and echocardiogram.

Sudden cardiac arrest patients may demonstrate brief myoclonic or seizure-like activity.


Before transportation to a hospital, emergency medical services (EMS) or lay people may utilize an automated external defibrillator (AED). Once EMS arrives cardiac monitoring via ECG should occur.

Full cardiac assessment is required for cardiac arrest survivors. The following tests should be completed to establish a cause :

  • ECG
  • Echocardiogram
  • Coronary angiography
  • Exercise test
  • Electrophysiology testing
  • Cardiac MRI
  • Genetic testing if ARVC, Brugada syndrome, CPVT, or LQTS are found
  • Cardiac biopsy may be considered if no other cause is found

ECG testing helps determine a diagnosis of ischemic heart disease, myocardial infarction, and inherited channelopathies. Echocardiograms evaluate for evidence of heart failure, cardiomyopathy, valvular heart disease, and congenital heart disease. Coronary angiography further evaluates coronary artery disease, congenital coronary anomalies, and coronary spasms. Exercise testing is helpful for diagnosis of ischemic heart disease, LQTS, and CPVT. Electrophysiology studies can detect the suspected arrhythmia. Procainamide can provoke Brugada syndrome regardless of the findings on the initial ECG. Cardiac MRI can detect ARVC, sarcoidosis (fibrotic cardiomyopathy), myocarditis, and myocardial injury from coronary spasms.

Treatment / Management

Treatment for sudden cardiac arrest should be initiated immediately by lay people and EMS. Treatment includes the use of an automated external defibrillator and cardiopulmonary resuscitation (CPR). CPR provides enough oxygen to the brain until a stable electrical rhythm can be established.

After transfer to a hospital, therapeutic hypothermia can be induced to limit neurologic injury and reperfusion injuries. Therapeutic hypothermia is more effective for the management of ventricular tachycardia and ventricular fibrillation but can also be used in PEA and asystole. Limitations to therapeutic hypothermia include a tympanic membrane temperature below 30 degrees at presentation, being comatose before the sudden cardiac arrest, pregnancy, inherited coagulation disorder, and the terminally ill patient.

If a patient survives the out-of-hospital cardiac arrest, long-term treatment is aimed at the underlying cause.

An implantable cardioverter defibrillator (ICD) is used for secondary prevention of sudden cardiac death in any person who has experienced arrhythmia-related syncope or survived sudden cardiac arrest.

Medication is targeted at the underlying cause of sudden cardiac arrest.

Differential Diagnosis

  • Angina Pectoris
  • Aortic Stenosis
  • Dilated Cardiomyopathy
  • Ebstein Anomaly
  • Hypertrophic Cardiomyopathy
  • MI
  • Teratology of Fallot
  • Ventricular Fibrillation
  • Ventricular Premature Complexes
  • Ventricular Tachycardia
  • Woff-Parkinson-White Syndrome


The overall out-of-hospital survival for sudden cardiac arrest is around 7%.

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