Linking To And Embedding Neurogal MD's "Can Lithium Prevent Alzheimer’s? | Neurologist Explains New 2025 Study"

Please review Lithium deficiency and the onset of Alzheimer’s disease [the subjct of today’s youtube post]. [PubMed Abstract] [Full-Text HTML] [Full-Text PDF]. Nature. 2025 Sep;645(8081):712-721. doi: 10.1038/s41586-025-09335-x. Epub 2025 Aug 6.

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Abstract

The earliest molecular changes in Alzheimer’s disease (AD) are poorly understood^1-5. Here we show that endogenous lithium (Li) is dynamically regulated in the brain and contributes to cognitive preservation during ageing. Of the metals we analysed, Li was the only one that was significantly reduced in the brain in individuals with mild cognitive impairment (MCI), a precursor to AD. Li bioavailability was further reduced in AD by amyloid sequestration. We explored the role of endogenous Li in the brain by depleting it from the diet of wild-type and AD mouse models. Reducing endogenous cortical Li by approximately 50% markedly increased the deposition of amyloid-β and the accumulation of phospho-tau, and led to pro-inflammatory microglial activation, the loss of synapses, axons and myelin, and accelerated cognitive decline. These effects were mediated, at least in part, through activation of the kinase GSK3β. Single-nucleus RNA-seq showed that Li deficiency gives rise to transcriptome changes in multiple brain cell types that overlap with transcriptome changes in AD. Replacement therapy with lithium orotate, which is a Li salt with reduced amyloid binding, prevents pathological changes and memory loss in AD mouse models and ageing wild-type mice. These findings reveal physiological effects of endogenous Li in the brain and indicate that disruption of Li homeostasis may be an early event in the pathogenesis of AD. Li replacement with amyloid-evading salts is a potential approach to the prevention and treatment of AD.

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Conflict of interest statement

Competing interests: The authors declare no competing interests.

Today, I review, link to, and embed Neurogal MD‘s Can Lithium Prevent Alzheimer’s? | Neurologist Explains New 2025 Study.

All that follows is from the above resource.

Can Lithium Prevent Alzheimer’s? | Neurologist Explains New 2025 Study

Neurogal MD

Aug 22, 2025

A new study published in Nature (Aug 2025) suggests that lithium may play an important role in brain health and protection against Alzheimer’s disease. In this video, I explain how researchers discovered natural lithium in the human brain, what happens when levels are low, and why lithium orotate showed promising effects in Alzheimer’s mouse models.

For more on lithium supplementation and my recommended brands, watch this video: • Lithium | Neurologist Reviews Evidence and…

DISCLAIMER: This video is for informational purposes only and reflects my review of available literature and personal experiences. It does not constitute medical advice. Please consult a healthcare provider for personalized recommendations.