Here are the resources from the Agency for Healthcare Research and Quality’s (AHRQ) Effective Health Care Program for Treatment Resistant Depression.

Consumer Guides on Health Conditions

1. Therapies for Treatment-Resistant Depression: A Review of the Research
2. Treatment Options When Your SSRI Antidepressant Is Not Working Well
3. Medicines for Treating Depression: A Review of the Research for Adults
4. Medicines for Treating Mental Health Conditions: A Review of the Research for Adults and Caregivers
5. Antipsychotic Medicines for Treating Schizophrenia and Bipolar Disorder: A Review of the Research for Adults and Caregivers
6. Antipsychotic Medicines for Children and Teens: A Review of the Research for Parents and Caregivers

Clinician Guides on Health Conditions

1. Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults
2. Treatment for Depression After Unsatisfactory Response to SSRIs in Adults and Adolescents
3. Second-Generation Antidepressants for Treating Adult Depression: An Update
4. Off-Label Use of Atypical Antipsychotics: An Update
5. First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness
6. First- and Second-Generation Antipsychotics for Children: Comparative Effectiveness

Summaries, Methods, and Reports

1. Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults
2. Addressing Knowledge Gaps in the Treatment of Depression
3. Treatment for Depression After Unsatisfactory Response to SSRIs
4. Treatment for Bipolar Disorder
5. Use of Quality Measures and Improved Outcomes in the Seriously Mentally Ill
6. Second-Generation Antidepressants in the Pharmacologic Treatment of Adult Depression: An Update of the 2007 Comparative Effectiveness Review
7. Nonpharmacological Versus Pharmacological Treatments for Adult Patients With Major Depressive Disorder
8. Psychological Treatments and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder (PTSD)
9. Treatment of Depression During Pregnancy and the Postpartum Period
10. Efficacy and Comparative Effectiveness of Off-Label Use of Atypical Antipsychotics – Update
11. First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness
12. First- and Second- Generation Antipsychotics for Children and Young Adults