In today’s New York Times* there is an excellent article about Dr. Nancy Wexler**, an outstanding researcher who advanced the study of Huntinton’s disease. Because of her work and the work of her team of investigators, we may soon have a treatment for this debilitating disease.
*I strongly suggest that every citizen consider subscribing to the New York Times.
**Haunted by a Gene, By Denise Grady. Published March 10, 2020. Updated March 11, 2020 from The New York Times.
The place to start after reviewing the above New York Times article is the exciting and hopeful Scientific American article, Antisense Drugs for Huntington’s, ALS and Prion Diseases Could Meet the Dire Need for Brain Treatments.
Antisense drugs are the most exciting development in medicine.
(1) Antisense Drugs for Huntington’s, ALS and Prion Diseases Could Meet the Dire Need for Brain Treatments [Full Text HTML]. By Bret Stetka on
A genetic therapy that increases or lowers levels of a protein raises hopes for a treatment for neurological disorders.
(2) Targeting Huntingtin Expression in Patients with Huntington’s Disease [PubMed Abstract] [Full Text HTML]. N Engl J Med. 2019 Jun 13;380(24):2307-2316.
The above article has been cited by 22 PubMed Central articles.
(3) Oligonucleotide Treatment for Huntington’s Disease [Full Text PDF].
(4) Roche Suspends Phase 1 Trial Testing Tominersen (RG6042) for Huntington’s [Full Text HTML]. March 12, 2020 from Huntington’s Disease News.