The Curbsiders Discuss The Sprint Trial – Episode 2 With Additional Resources

Here is the link to the SPRINT Trial website and here are direct links from the site:

Information about the SPRINT Blood Pressure Intervention

SPRINT AGS Slides (May 2016)

SPRINT AHA Slides (November 2015)

NIH Press Release (September 11, 2015)

SPRINT Design Paper

Intensive Blood Pressure Control in SPRINT Participants

Treatment Algorithm

SPRINT Formulary

MOP versions related to SPRINT blood pressure measurement technique

Letter to Participant (English)

Letter to Health Care Provider (English)

Letter to Participant (Spanish)

Letter to Health Care Provider (Spanish)

And here are my posts related to the SPRINT trial:

Methods of the SPRINT MIND Trial – How They Did It + Why It Matters to Primary Care Physicians
Posted on November 24, 2015 by Tom Wade MD

The SPRINT Treatment Algorithm for the Intensive Treatment Group (Goal SBP < 120 mm Hg) – How They Did It
Posted on November 14, 2015 by Tom Wade MD

In this post I link to and excerpt from the Curbsiders’ podcast and show notes from #2: Are You Treating Hypertension Adequately? Discussing the Implications of SPRINT. [Link is to the podcast and show notes.]

Here are excerpts:

Take home points:

  1. Intensive systolic BP control decreased cardiovascular death, all-cause mortality, CHF
  2. Beware about relaxing systolic BP goals (as recommended by JNC 8) in older patients with high CV risk*,**
  3. In this trial, blood pressures were measured three times by an automatic cuff with patient seated, resting alone in an exam room (despite this fact, an average systolic BP goal of less than 120 mmHg was not reached in the trial)

*SPRINT included: Patients over 50 years old with any of the following: eGFR 20-60 ml/min, symptomatic or asymptomatic CV disease, age 75 years old or greater, Framingham 10 year Risk above 15%

**SPRINT excluded: institutionalized adults, patients with diabetes, active malignancy, proteinuria, or prior stroke

SPRINT Trial Basics:

  • Randomized, controlled trial of 9,361 patients to Intensive (systolic BP under 120) versus Standard (systolic BP under 140) BP control. The trial was stopped early after 3.3 years due to a significant decrease in the primary outcome for the Intensive treatment group.
  • Primary Outcome: composite of MI, ACS, stroke, heart failure, cardiovascular death.
  • Adverse events that were more common in the Intensive treatment group included: hypotension, acute kidney injury and syncope. There was NOT an increase in orthostasis or injurious falls in the Intensive treatment group.

[Selected and Additional] Recommended References:

The SPRINT Research Group. A Randomized Trial of Intensive versus Standard Blood-Pressure Control. N Engl J Med 2015;373:2103-2116. [PubMed Abstract] [Full Text HTML] [Full Text PDF]

The above article has been cited by 1,064 articles in PubMed Central.*

*You can sort the above overwhelming numbers at the link by date of publication and many other useful sorting tools.

[Summary of] Systolic Blood Pressure Intervention Trial – SPRINT, Nov 13, 2017 from The Latest In Cardiology by The American College of Cardiology.



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