Here is the link to the SPRINT Trial website and here are direct links from the site:
Information about the SPRINT Blood Pressure Intervention
And here are my posts related to the SPRINT trial:
Methods of the SPRINT MIND Trial – How They Did It + Why It Matters to Primary Care Physicians
Posted on November 24, 2015 by Tom Wade MD
The SPRINT Treatment Algorithm for the Intensive Treatment Group (Goal SBP < 120 mm Hg) – How They Did It
Posted on November 14, 2015 by Tom Wade MD
In this post I link to and excerpt from the Curbsiders’ podcast and show notes from #2: Are You Treating Hypertension Adequately? Discussing the Implications of SPRINT. [Link is to the podcast and show notes.]
MARCH 1, 2016 By MATTHEW WATTO, MD
Here are excerpts:
Take home points:
- Intensive systolic BP control decreased cardiovascular death, all-cause mortality, CHF
- Beware about relaxing systolic BP goals (as recommended by JNC 8) in older patients with high CV risk*,**
- In this trial, blood pressures were measured three times by an automatic cuff with patient seated, resting alone in an exam room (despite this fact, an average systolic BP goal of less than 120 mmHg was not reached in the trial)
*SPRINT included: Patients over 50 years old with any of the following: eGFR 20-60 ml/min, symptomatic or asymptomatic CV disease, age 75 years old or greater, Framingham 10 year Risk above 15%
**SPRINT excluded: institutionalized adults, patients with diabetes, active malignancy, proteinuria, or prior stroke
SPRINT Trial Basics:
- Randomized, controlled trial of 9,361 patients to Intensive (systolic BP under 120) versus Standard (systolic BP under 140) BP control. The trial was stopped early after 3.3 years due to a significant decrease in the primary outcome for the Intensive treatment group.
- Primary Outcome: composite of MI, ACS, stroke, heart failure, cardiovascular death.
- Adverse events that were more common in the Intensive treatment group included: hypotension, acute kidney injury and syncope. There was NOT an increase in orthostasis or injurious falls in the Intensive treatment group.
[Selected and Additional] Recommended References:
The above article has been cited by 1,064 articles in PubMed Central.*
*You can sort the above overwhelming numbers at the link by date of publication and many other useful sorting tools.