Analogue insulin is a sub-group of human insulin. Analogue insulin is laboratory grown but genetically altered to create either a more rapid acting or more uniformly acting form of the insulin.
This can have advantages for blood sugar management
Analogue insulins have been available since just before the start of the new millennium.
HOW IS HUMAN ANALOGUE INSULIN PRODUCED?
Similar to human insulin , analogue insulin is laboratory created by growing insulin proteins within E-coli bacteria (Escherichia coli).
The process goes further through changing the order of amino acids to allow the insulin to be used by the body either more rapidly or more uniformly by the body than with regular human insulin.
This type of process is known as undergoing ‘recombinant DNA’ technology.
WHAT TYPES OF ANALOGUE INSULIN ARE AVAILABLE?
Analogue insulin is available in two main forms, rapid acting and long acting, as well as premixed combinations.
Examples of analogue insulin:
- Rapid acting: Humalog, NovoRapid
- Long acting: Lantus, Levemir, Tresiba
- Premixed analogue insulins: Humalog Mix 25, Humalog Mix 50, NovoMix 30
WHAT ARE PREMIXED ANALOGUE INSULINS?
Premixed analogue insulins combine a ratio of rapid acting and long acting insulin.
For example, Humalog Mix 25 consists of 25% rapid acting and 75% long acting insulin.
HOW QUICKLY DO ANALOGUE INSULINS ACT?
Rapid acting insulins start to act immediately after injecting , with their peak action occurring within the first hour after injecting.
The duration is up to 4 hours.
Long acting insulin takes about 2 hours to start acting, and is designed to act uniformly so that there is no peak activity as such. The duration of long acting insulin is up to 24 hours. Your healthcare team will be able to advise whether you need one or two doses per day.
BENEFITS OF ANALOGUE INSULIN
The primary benefits of analogue insulin are that the rapid acting insulin works as soon as it is injected and long acting insulins have no peak activity.
Rapid acting insulin is particularly useful for people who are insulin dependent as it can help to minimise sharp rises (spikes) in blood sugar shortly after eating.
Long acting analogue insulins have become popular partly because the lack of a peak activity period allows for easier prediction of how it acts and has also gives some people more confidence that they will avoid night time hypos
DISADVANTAGES OF ANALOGUE INSULIN
As with human insulins, it has been reported that analogue insulins may lead to unwanted side effects such as loss of hypo awareness, lethargy and weight gain that might not be found when taking animal insulins.
To date, no conclusive research to confirm or deny this claim is available. Analogue insulins are still a relatively new treatment and therefore there is a lack of long term research. In 2009, a four country study highlighted a potential link between the use of Lantus and the development of cancer
However, after the research was reviewed, the European Medicines Agency found the studies to not be consistent enough to either confirm or deny the link, and therefore cleared Lantus as being safe for use.
PRICE OF ANALOGUE INSULIN
A further disadvantage of analogue insulin is in its price. Analogue insulins cost the NHS over twice as much as non-analogue human insulins.
Follow Tom On:
- Links To And Excerpts From The Curbsiders’ #194 Alcohol Use Disorder Treatment with Dr. Marlene Martin
- Links To Resources For The Drink-Less Program From The Alcohol Use Disorders Identification Test Website
- Links To And Excerpts From The Alcohol Use Disorders Identification Test (AUDIT) Website
- Links To And Excerpts From The Curbsiders’ Preventive Medicine Update #251 “What Is The USPTF?”
- 5 Reasons to Wear A Mask Even After Your Vaccinated From Kaiser Health News
- Link To “Congestive Heart Failure in Canines” From Today’s Veterinary Practice
- Link To The Outstanding YouTube Video By Dr. Hansen – “Doctor Dies 16 Days After Getting COVID19 Vaccine”
- Links To And Excerpts From 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS)
- Link To “‘Stop the Steal’ Didn’t Start With Trump” From The New York Times
- Link To EMCrit –George Kovacs on Ketamine-Facilitated Intubation (KFI) With Additional Resources
- Links To Two EMCrit Posts On Ketamine Only Intubation
- Links To And Excerpts From Reversal of direct oral anticoagulants: Guidance from the Anticoagulation Forum
- Links To And Excerpts From Direct Oral Anticoagulant Use: A Practical Guide to Common Clinical Challenges
- Links To BCE 47 – Cyanotic Infant And EMC Episode 84 – Congenital Heart Disease Emergencies With Additional Links
- Resources On The Evaluation of Transient Synovitis of the Pediatric Hip
- Links To And Excerpts From “A general approach to resuscitation” From First10 EM
- Complete List With Links To Best Case Ever Series From Emergency Medicine Cases
- Links To And Excerpts From Episode 85 – Medical Clearance of the Psychiatric Patient From Emergency Medicine Cases
- Links To And Excerpts From The association between patterns of atrial fibrillation, anticoagulation, and cardiovascular events
- Links To And Excerpts From Emergency Medicine Cases’ Episode 86 – Emergency Management of Hyperkalemia
- Links To And Excerpts From Episode 87 – Alcohol Withdrawal and Delirium Tremens: Diagnosis and Management From Emergency Medicine Cases
- A Great Summary And Checklist On The Prescription Of Anticoagulation For DVT And Atrial Fibrillation From Emergency Medicine Cases 88
- Review Of Best Case Ever 51, 50, 49, 48, and 47 From Emergency Medicine Cases With Additional Resources
- Links To “Thomas Piketty, Paul Krugman and Joseph Stiglitz: The Genius of Economics”
- Best Ever! – The PREPARE Algorithms For Airway Management From BCE 57
- Chart – Medications For Airway Management From BCE 57 Of Emergency Medicine Cases
- “Just A Routine Operation” With A Tragic Outcome – YouTube Video By Martin Brimley With Two Additional Resources
- Links To The Montreal Cognitive Assessment For The Detection Mild Cognitive Impairment
- Acute Renal Failure With Volume Overload [Pulmonary Edema] In A Small Hospital With No Dialysis Capability – What Can You Do
- Link To And Excerpts From “Private Equity Buyouts in Healthcare: Who Wins, Who Loses?”