In addition to today’s resoure, I have included links to additional resources on cognitive disorders throughout the post.
Today, I link to, review, and excerpt from the web page, Consulting the Memory and Cognitive Disorders Clinic,* from the University of Florida Department of Neurology. Accessed 12/21/2023.
*This web page contains information for physicians who want to refer a patient to The Memory and Cognitive Disorders Clinics. The Consulting the Memory and Cognitive Disorders Clinic web page is an excellent resource on how to initiate an evaluation for a patient with a possible memory disorder as well as for how to initiate a referral to the clinic.
All that follows is from the above resource.
Consulting the Memory and Cognitive Disorders Clinic
Here are some tips to expedite the Memory and Cognitive Disorders initial evaluation.
Consultation Requests
- Specify Memory and Cognitive Disorders Clinics within neurology on the request. May abbreviate to MCDC.
- If dementia or mild cognitive impairment is suspected, include in the consult request.
- Consider parallel consultation to our UF Health neuropsychology department with Dr. David Loring. Specify Dementia Protocol.
Brain MRI
- We will want to see an MRI of the brain. If one has not been done recently (within past year and after complaint began), consider ordering one.*
- For MRIs ordered at UF Health, indicate the Dementia Protocol on the MRI order.
- If a Brain MRI within the last year and after the onset of symptoms has not been done, we will be happy to order one for you.
*For information on a dementia protocol MRI scan, please see “Dementia – Role of MRI” From Radiology Assistant. Posted on December 19, 2023 by Tom Wade MD
Laboratory studies typically ordered for memory/cognitive evaluation
Do you need to order these?
No, we will be happy to do so for you.
Will it expedite your patient’s work-up?
Yes.
- ANA and RF
- ApoE Genotype (available through Athena Labs)*
*ADmark® ApoE Genotype Analysis and Interpretation (Symptomatic)
- B-12*
*Low Vitamin B12 Levels: An Underestimated Cause Of Minimal Cognitive Impairment And Dementia. Cureus. 2020 Feb 13;12(2):e6976. doi: 10.7759/cureus.6976. [PubMed Abstract] [Full-TextHTML] [Full-Text PDF].
The above article has been cited by twelve articles in PubMed.
There are 95 similar articles in PubMed.
- CBC w/ diff
- CMP and Mag/Phos
- ESR
- Folate*
*The Association Between Folate and Alzheimer’s Disease: A Systematic Review and Meta-Analysis. Front Neurosci. 2021 Apr 14:15:661198. doi: 10.3389/fnins.2021.661198. eCollection 2021. [Pubed Abstract] [Full-Text HTML] [Full-Text PDF].
The above article has been cited by thirteen articles in PubMed.
There are 92 similar articles in PubMed.
- HgA1C
- Homocysteine*
*Homocysteine and Dementia: An International Consensus Statement. J Alzheimers Dis. 2018;62(2):561-570. doi: 10.3233/JAD-171042. [PubMed Abstract] [Full-Text HTML] [Full-Text PDF].
The above article has been cited by 111 articles in PubMed.
There are 216 similar articles in PubMed.
*Homocysteine, Cognitive Functions, and Degenerative Dementias: State of the Art. Biomedicines. 2022 Oct 28;10(11):2741. doi: 10.3390/biomedicines10112741. [PubMed Abstract] [Full-Text HTML] [Full-Text PDF]
The above article has been cited by seven articles in PubMed.
There are 97 similar articles in PubMed.
- Lipid Panel
- TFT*
*TFT-thyroid function tests
- Thiamine*
*Supplemental thiamine as a practical, potential way to prevent Alzheimer’s disease from commencing. Alzheimers Dement (N Y). 2021 Jul 28;7(1):e12199. doi: 10.1002/trc2.12199. eCollection 2021. [PubMed Abstract] [Full-Text HTML] [Full-Text PDF].
The above resource has been cited by four articles in PubMed.
There are 77 similar articles in PubMed.
- TPPA*
*TPPA-alpha tocopherol transfer protein:
TTPa is a soluble protein that binds alpha-trocopherol, a form of vitamin E, with high selectivity and affinity. TTPa plays an important role in regulating vitamin E levels in the body by transporting vitamin E between membrane vesicles and facilitating the secretion of vitamin E from hepatocytes to circulating lipoproteins. Mutations in TTPa cause hereditary vitamin E deficiency and retinitis pigmentosa. The Assay Genie TTPa ELISA is a highly sensitive assay for the quantitative measurement of TTPa in serum, blood, plasma, cell culture supernatant and tissue samples.
*Role of Vitamin E in the Treatment of Alzheimer’s Disease: Evidence from Animal Models. Int J Mol Sci. 2017 Nov 23;18(12):2504. doi: 10.3390/ijms18122504. [PubMed Abstract] [Full-Text HTML] [Full-Text PDF].
