Review of Two Different Antinuclear Antibody Test Results

For further information on Antinuclear Antibody Testing, please see:

I was asked to review an extensive set of laboratory and imaging evaluations triggered by a low white count.

The patient’s rheumatologist saw the patient several days ago and stated that all her tests were negative and that she did not have a connective tissue disorder.

I simply went over with the patient why the tests were ordered and why they were all normal.

Tests ordered by the patient’s hematologist were  antinuclear antibody tests on 8-25-2020  was reported as:

ANA Screen, IFA     Positive    Normal result is negative

Lab Comment: ANA IFA is a first line screen for detecting up to 150 autoantibodies in various autoimmune diseases. A positive ANA IFA is suggestive of autoimmune disease and reflexes to titer and pattern.

ANA Titer        1:80

ANA Pattern    Nuclear, Speckled

And on 9-30-2020, her rheumatologist ordered the following:

 09/30/2020Cardiolipin, antibody, each lg classCompleted
 09/30/2020Cardiolipin, antibody, each lg classCompleted
 09/30/2020Uric Acid; BloodCompleted
 09/30/2020C-Reactive Protein ( Crp )Completed
 09/30/2020Comprehensive Metabolic PanelCompleted
 09/30/2020Urinalysis /wo Micro RoutineCompleted
 09/30/2020ANA (antinuclear Antibodies )Completed
 09/30/2020Extractable nuclear antigen, each AntibodyCompleted
 09/30/2020Cyclic citrullinated peptide, antibodyCompleted
 09/30/2020Cardiolipin, antibody, each lg classCompleted
 09/30/2020Microsomal antibodies, eachCompleted
 09/30/2020Complement AntigenCompleted
 09/30/2020Rheumatoid Factor;qauntitativeCompleted

It is not clear what laboratory the blood was sent to. I will attempt to contact the rheumatologist who ordered the tests below. Then I can ask the lab about the performance characteristics of the ANA ANTIBODY SCREEN QUANT and the other tests that follow.

I assume that the tests that follow below were automated tests of ANA and the subsequent tests reflexed when the ANA was positive.



This entry was posted in Decision Aids, Laboratory Tests, Rheumatology. Bookmark the permalink.