In addition to today’s post, please review Links To And Excerpts From “Supplemental thiamine as a practical, potential way to prevent Alzheimer’s disease from commencing” With Links To Additional Resources
Posted on July 13, 2022 by Tom Wade MD
In this post, I link to and excerpt from Neurological, Psychiatric, and Biochemical Aspects of Thiamine Deficiency in Children and Adults [PubMed Abstract] [Full-Text HTML] [Full-TextPDF]. Front Psychiatry. 2019; 10: 207. Published online 2019 Apr 4. doi: 10.3389/fpsyt.2019.00207
There are 85 similar articles in PubMed for the above article.
All that follows is from the above resource.
Abstract
Thiamine (vitamin B1) is an essential nutrient that serves as a cofactor for a number of enzymes, mostly with mitochondrial localization. Some thiamine-dependent enzymes are involved in energy metabolism and biosynthesis of nucleic acids whereas others are part of the antioxidant machinery. The brain is highly vulnerable to thiamine deficiency due to its heavy reliance on mitochondrial ATP production. This is more evident during rapid growth (i.e., perinatal periods and children) in which thiamine deficiency is commonly associated with either malnutrition or genetic defects. Thiamine deficiency contributes to a number of conditions spanning from mild neurological and psychiatric symptoms (confusion, reduced memory, and sleep disturbances) to severe encephalopathy, ataxia, congestive heart failure, muscle atrophy, and even death. This review discusses the current knowledge on thiamine deficiency and associated morbidity of neurological and psychiatric disorders, with special emphasis on the pediatric population, as well as the putative beneficial effect of thiamine supplementation in autism spectrum disorder (ASD) and other neurological conditions.
Keywords: Krebs cycle; autism spectrum disorders; brain; depressive disorders; encephalomyopathies; pentose phosphate pathway; thiamine transporter.
