Link To The NICE 2020 Table Of Contents Of DEPRESSION THE TREATMENT AND MANAGEMENT OF DEPRESSION IN ADULTS (UPDATED EDITION) National Clinical Practice Guideline 90

In this post, I link to the National Institute for Health & Clinical Excellence [NICE] DEPRESSION: THE TREATMENT AND MANAGEMENT OF DEPRESSION
IN ADULTS (UPDATED EDITION). National Clinical Practice Guideline 90 [Full Text PDF]. 2020.

I’ll be reviewing this document in the upcoming days.  I’ve included a copy of the front piece and the table of contents for my reference.

All that follows is from the above:

CONTENTS
GUIDELINE DEVELOPMENT GROUP MEMBERS 7
ACKNOWLEDGEMENTS 10
1 PREFACE 11
1.1 National guidelines 11
1.2 The national depression guideline 14
2 DEPRESSION 17
2.1 The disorder 17
2.2 Aetiology 25
2.3 Economic costs of depression 26
2.4 Treatment and management in the National Health Service 28
3 METHODS USED TO DEVELOP THIS GUIDELINE 34
3.1 Overview 34
3.2 The scope 34
3.3 The Guideline Development Group 35
3.4 Clinical questions 37
3.5 Systematic clinical literature review 38
3.6 Health economics methods 47
3.7 Methods for reviewing experience of care 49
3.8 Stakeholder contributions 51
3.9 Validation of the guideline 51
4 EXPERIENCE OF CARE 52
4.1 Introduction 52
4.2 Personal accounts – people with depression 52
4.3 Personal accounts – carers 68
4.4 Qualitative analysis 71
4.5 Review of the qualitative literature 83
4.6 From evidence to recommendations 86
4.7 Recommendations 94
5 CASE IDENTIFICATION AND SERVICE DELIVERY 97
5.1 Introduction 97
5.2 The identification of depression in primary care and
community settings 98
5.3 Service delivery systems in the treatment and management
of depression 121
5.4 Stepped care 124
5.5 Collaborative care 129
Contents
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5.6 Medication management 141
5.7 Crisis resolution and home treatment teams 146
5.8 Acute day hospital care 149
5.9 Non-acute day hospital care 151
5.10 Non-statutory support 153
5.11 Research recommendation 155
6 INTRODUCTION TO PSYCHOLOGICAL AND
PSYCHOSOCIAL INTERVENTIONS 157
6.1 Introduction 157
6.2 Recommending psychological and psychosocial treatments 157
6.3 How do psychological and psychosocial interventions
become evidence based? 158
6.4 Contextual factors that impact on clinical practice 164
6.5 Databases searched and inclusion/exclusion criteria 168
6.6 Studies considered 168
7 LOW-INTENSITY PSYCHOSOCIAL INTERVENTIONS 170
7.1 Computerised cognitive behavioural therapy 170
7.2 Guided self-help 181
7.3 Physical activity programmes 190
7.4 From evidence to recommendations – low-intensity
psychosocial interventions 212
7.5 Recommendations 213
8 HIGH-INTENSITY PSYCHOLOGICAL INTERVENTIONS 215
8.1 Cognitive behavioural therapies 215
8.2 Behavioural activation 238
8.3 Problem solving 242
8.4 Couples therapy 246
8.5 Interpersonal therapy 249
8.6 Counselling 261
8.7 Short-term psychodynamic psychotherapy 267
8.8 Rational emotive behavioural therapy 272
8.9 Economic modelling 274
8.10 From evidence to recommendations 291
8.11 Recommendations 296
8.12 Research recommendations 300
9 INTRODUCTION TO PHARMACOLOGICAL AND PHYSICAL
INTERVENTIONS 304
9.1 Introduction 304
9.2 Dose and duration of antidepressant treatment: evidence
from clinical practice 306
9.3 Limitations of the literature: problems with randomised
controlled trials in pharmacology 308
9.4 Studies considered for review – additional inclusion criteria 309
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9.5 Issues and topics covered by this review 311
9.6 Placebo-controlled randomised controlled trials of antidepressants 313
9.7 Selective serotonin reuptake inhibitors versus placebo 315
9.8 Tricyclic antidepressants versus placebo 319
9.9 From evidence to recommendations 326
9.10 Recommendation 327
10 PHARMACOLOGICAL INTERVENTIONS 328
10.1 Introduction 328
10.2 Use of individual drugs in the treatment of depression 329
10.3 Tricyclic antidepressants 330
10.4 Selective serotonin reuptake inhibitors 336
10.5 Escitalopram 341
10.6 The thread study 354
10.7 Monoamine oxidase inhibitors 354
10.8 Third-generation antidepressants 360
10.9 St John’s wort 387
10.10 Health economics evidence 391
10.11 Network meta-analysis of newer antidepressants 398
10.12 Economic model for the cost-effectiveness of
pharmacological interventions for people with depression 399
10.13 From evidence to recommendations 411
10.14 Clinical practice recommendations 412
10.15 When to change antidepressant treatment when symptoms
of depression are not improving 413
11 FACTORS INFLUENCING CHOICE OF ANTIDEPRESSANTS 418
11.1 Introduction 418
11.2 The pharmacological management of depression in older adults 418
11.3 The effect of sex on antidepressant choice 424
11.4 The pharmacological management of depression with
psychotic symptoms 425
11.5 The pharmacological management of atypical depression 427
11.6 The physical and pharmacological management of depression
with a seasonal pattern 430
11.7 Dosage issues for tricyclic antidepressants 451
11.8 Antidepressant discontinuation symptoms 453
11.9 The cardiotoxicity of antidepressants 457
11.10 Depression, antidepressants and suicide 462
12 THE PHARMACOLOGICAL AND PHYSICAL MANAGEMENT OF
DEPRESSION THAT HAS NOT ADEQUATELY RESPONDED TO
TREATMENT, AND RELAPSE PREVENTION 466
12.1 Introduction 466
12.2 Approach to the reviews 467
12.3 Pharmacological ‘next-step’ treatment for depression that has
not adequately responded to treatment 469
Contents
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12.4 Electroconvulsive therapy 508
12.5 Other non-pharmacological physical treatments 528
12.6 The pharmacological management of relapse prevention 530
13 THE MANAGEMENT OF SUBTHRESHOLD DEPRESSIVE
SYMPTOMS 536
13.1 Introduction 536
13.2 Pharmacological interventions for subthreshold depressive
symptoms and persistent subthreshold depressive symptoms
(dysthymia) 537
13.3 Psychological and other strategies for the treatment of
persistent subthreshold depressive symptoms (dysthymia) 555
13.4 From evidence to recommendations 563
13.5 Recommendations 564
13.6 Research recommendation 564
14 SUMMARY OF RECOMMENDATIONS 565
14.1 Care of all people with depression 565
14.2 Stepped care 567
14.3 Step 1: recognition, assessment and initial management 568
14.4 Step 2: recognised depression – persistent subthreshold
depressive symptoms or mild to moderate depression 569
14.5 Step 3: persistent subthreshold depressive symptoms or mild to
moderate depression with inadequate response to initial
interventions, and moderate and severe depression 571
14.6 Treatment choice based on depression subtypes and
personal characteristics 576
14.7 Enhanced care for depression 576
14.8 Sequencing treatments after initial inadequate response 577
14.9 Continuation and relapse prevention 579
14.10 Step 4: complex and severe depression 582
14.11 Research recommendations 585
15 APPENDICES 591
16 REFERENCES 647
17 ABBREVIATIONS 696
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